Overcoming the AAV Capacity Challenge

Time: 9:00 am
day: Delivery Stream 1


  • An overview of the gene-carrying capacities of commonly used vectors in ocular gene therapy delivery
  • Acknowledging the limited packaging size of AAV vectors, what are the benefits and drawbacks of dual AAV approaches?
  • Exploring protein splicing AAV gene therapy for large gene delivery, and their potential benefits
  • Understanding novel, non-viral, large-gene delivery approaches, their potential benefits as well as toxicity challenges