XIAP Anti-Apoptotic Gene Therapy for the Treatment of Glaucoma

Time: 1:50 pm
day: Preclinical 4


  • Using gene therapy to target apoptosis of the cell (the final endpoint for many ocular diseases) is a general strategy that doesn't target a specific mutation
  • The X-linked inhibitor of apoptosis (XIAP) is able to block apoptosis by preventing caspase activation, but can also block necroptosis and inflammasome formation
  • XIAP gene therapy is effective in protecting retinal ganglion cell structure and function in a mouse model of glaucoma and represents a general therapy that can be used to target various forms of retinal disease, irrespective of underlying pathology