Engineering Advanced Capsid Technologies to Overcome Ocular Barriers & Enhance Scalability
Time: 2:00 pm
day: Pre-Conference Workshop Day
Details:
Current vectors face the restriction of the blood-retinal-barriers when injecting into the eye. Therefore, the advancement of AI and large data provides efficient and creative way to pass through this boundary. This workshop examines engineered capsids using highthroughput multiplexing and machine learning approaches to achieve effective delivery at lower doses with reduced inflammatory responses.
Key Discussion Points:
- Harnessing high-throughput multiplexing and machine learning to engineer nextgeneration AAV capsids for intravitreal gene therapy delivery
- Developing engineered capsids that penetrate the inner limiting membrane barrier to enable effective intravitreal delivery
- Implementing high-throughput screening platforms that evaluate capsid variants simultaneously to accelerate discovery beyond traditional approaches
- Integrating machine learning algorithms with capsid performance data to generate vectors achieving therapeutic efficacy at reduced doses
