Brahim Belbellaa

Company: Coave Therapeutics

Job title: Senior Director, Preclinical Ophthalmology

Seminars:

Preclinical Development of Engineered AAV Capsids via Suprachoroidal Delivery: Tiered Screening, PK/PD Prediction, & IND-Enabling Safety Strategy 3:45 pm

Outlining current AAV delivery challenges and the opportunity of suprachoroidal (SC) administration, driving the need for a novel preclinical drug development strategy Detailing a tiered in vitro-to-in vivo screening cascade (including NHP data) for PK/PD correlation and predicting human-equivalent biodistribution of novel capsids Establishing proof-of-concept efficacy and safety through complementary small and large animal models,…Read more

day: Conference Day One